Preformulation Services - Latitude Pharmaceuticals

Preformulation Services

LATITUDE’s preformulation services are designed to provide key information for formulating drug substances in both the solution phase and solid state.

Our solution phase program evaluates:

Solubility in pH buffers (pH-solubility profile)
Solubility in pharmaceutically useful solvents
Drug solubilizer screening
Determination of ionization constants
Determination of partition coefficients
Drug-excipient compatibility

Our solid state program evaluates:

Salt form selection
Morphology study
Hygroscopicity evaluation
Thermal characterization
Particle size and size distribution
Powder density, flowability and compressibility
Drug-excipient compatibility

LATITUDE’s efficient and unique approaches enable us to complete a preformulation study using minimum quantities of drug substance. A comprehensive preformulation evaluation, including analytical HPLC method development, typically requires as little as 1-2 grams of API.