Formulation

   Dosage form

   Preformulation

   Drug substances

   Analytical
   methods
   development

   Manufacturing

Preformulation

LATITUDE provides services for preformulation evaluation of drug substances in both solution phase and solid state.

Our solution phase program focuses on:

• Solubility in pH buffers (pH-solubility profile)
• Solubility in pharmaceutically useful solvents
• Drug solubilizer screening
• Determination of ionization constants
• Determination of partition coefficients
• Drug-excipient compatibility

The solid state program emphasizes on:

At LATITUDE, we have developed unique methods in performing the preformulation tasks with a minimum quantity of drug substance. Typically, a comprehensive preformulation evaluation can be completed, including analytical HPLC method development, using less than 1-2 grams of the drug substance.